- Title
- The Prognostic Utility of KRAS Mutations in Tissue and Circulating Tumour DNA in Colorectal Cancer Patients
- Creator
- Petit, Joel; Carroll, Georgia; Zhao, Jie; Pockney, Peter; Scott, Rodney J.
- Relation
- Gastroenterology Insights Vol. 15, Issue 1, p. 107-121
- Publisher Link
- http://dx.doi.org/10.3390/gastroent15010008
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2024
- Description
- This study aims to investigate the long-term prognostic utility of circulating tumour DNA (ctDNA) KRAS mutations in colorectal cancer (CRC) patients and compare this with KRAS mutations in matched tissue samples. Tumour tissue (n = 107) and ctDNA (n = 80) were obtained from patients undergoing CRC resection and were analysed for KRAS mutations. The associations between KRAS mutation and overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were analysed. All outcomes were measured in years (y). A total of 28.8% of patients had KRAS mutations in ctDNA and 72.9% in tumour tissue DNA. The high frequency of KRAS mutations in tissue samples was due to 51.4% of these being a detectable low mutation allele frequency (<10% MAF). Comparing KRAS mutant (KRASmut) to KRAS wild-type (KRASwt) in ctDNA, there was no association found with OS (mean 4.67 y vs. 4.34 y, p = 0.832), CSS (mean 4.72 y vs. 4.49 y, p = 0.747), or RFS (mean 3.89 y vs. 4.26 y, p = 0.616). Similarly, comparing KRASmut to KRASwt in tissue DNA there was no association found with OS (mean 4.23 y vs. 4.61 y, p = 0.193), CSS (mean 4.41 y vs. 4.71 y, p = 0.312), or RFS (mean 4.16 y vs. 4.41 y, p = 0.443). There was no significant association found between KRAS mutations in either tissue or ctDNA and OS, CSS, or RFS.
- Subject
- colorectal cancer; prognosis; tumour biomarkers; circulating cell-free DNA; circulating tumour-DNA; KRAS
- Identifier
- http://hdl.handle.net/1959.13/1500456
- Identifier
- uon:54935
- Identifier
- ISSN:2036-7422
- Language
- eng
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